Platelet Immunology
ISBT Education. Semple JW. Jun 20, 2017; 184739; ISBT-1265 Topic: Platelet biology
Disclosure(s): Consultant: Amgen, Novartis, Rigel
Prof. Dr. John Semple
Prof. Dr. John Semple
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After viewing this presentation the participant will be able to:

- Gain insight into the complex physiology of platelets and how they can be attacked by both autoimmune and alloimmune mechanisms

- Review the clinically significant haematological disorders that arise from an immune response against platelets
The immune response against platelets is a complex process involving many aspects of the innate and adaptive immune system. Immune destruction of platelets and megakaryocytes and the thrombocytopenia that ensues can cause different clinically significant haematological disorders such as transfusion-induced platelet refractoriness or immune thrombocytopenia (ITP). These conditions are frequently difficult to manage so an understanding of the biological nature of these adverse conditions is critical for an understanding of how to potentially reduce them. Superimposed on these immune platelet attack mechanisms are the immune characteristics of the platelets themselves. This lecture will give an overview of how the immune system recognizes platelet antigens and mounts efficient effector mechanism to mediate thrombocytopenia. It will also present new evidence to suggest that platelets also play a role in stimulating these responses and suppressing them; a scenario where the prey becomes the predator. The session will leave the audience with an appreciation of the various mechanisms of platelet immunity and attack and how they lead to serious clinical disorders.
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